Search Results - diagnostics

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Assays for the detection of Enterovirus D68
Researchers at TGen have developed assays for the detection of Enterovirus D68 (EV-D68) in complex patient samples.  Both PCR and amplicon sequencing assays rapidly diagnose patients with EV-D68 respiratory illness, and can be used to assess a patient’s risk of acute flaccid myelitis (AFM) and potentially diagnose AFM.  The assays can additionally be...
Published: 3/2/2020   |   Inventor(s): David Engelthaler, Jolene Bowers
Keywords(s):  
Category(s): Diagnostics
Biomarker Proxies for Standard Blood Chemistry Tests
Researchers at TGen have identified several RNA signatures that can be utilized to predict standard blood tests based on hematology or chemistry, for example, the results from a complete blood count panel, a comprehensive metabolic panel, a chemistry panel, or an endocrine panel (such as levels of thyroxine, T3, and TSH).  The expression of these RNA...
Published: 3/2/2020   |   Inventor(s): Matt Huentelman, Tim Mcdaniel, Marcus Naymik
Keywords(s):  
Category(s): Medical, Diagnostics
BioThreatSeq: an amplicon sequencing assay for detection and characterization of microbial pathogens in complex environmental and clinical samples
Researchers at TGen and Northern Arizona University have developed a  multi-agent multi-locus amplicon sequencing protocol encompassing 79 targets aimed at detecting the presence or absence of five major biothreat agents: Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, Yersinia pestis and Francisella tularensis, as well as the presence...
Published: 3/2/2020   |   Inventor(s): James Schupp, Jason Sahl, Paul Keim, David Engelthaler, David Wagner, Viacheslav Fofanov
Keywords(s):  
Category(s): Diagnostics
Molecular Assay for Diagnosing and Prognosing Esophageal Adenocarcinoma
Through a collaboration between TGen and Dignity Health, researchers have developed an assay for early detection and monitoring of Esophageal Adenocarcinoma (EA), which differentiates Metaplasia from Dysplasia patients and monitors progression of EA .  The identified panel of markers can be monitored non-invasively for uptake and release changes through...
Published: 4/9/2019   |   Inventor(s): Landon Inge, Timothy Whitsett, Patrick Pirrotte, Khyatiben (Khyati) Pathak
Keywords(s):  
Category(s): Diagnostics
Dried Blood Spot Sequencing to Identify RNA Biomarkers
Researchers at TGen have developed a simple and non-invasive approach to sequence RNA biomarkers from a single dried blood spot.  Using this RNA biomarker technology enables a relatively small volume biofluid sample from a patient (e.g., a drop of blood) to provide significant clinical information, such as identification, severity, stage, outcome, etc.,...
Published: 3/22/2019   |   Inventor(s): Matt Huentelman
Keywords(s):  
Category(s): Diagnostics
miRNA Biomarker for Detecting Increased Risk of Brain Metastasis in NSCLC Patients
Through a collaboration of TGen, Honor Health, and Arizona State University, a method for classifying a non-small cell lung cancer (NSCLC) patient as having an increased risk of brain metastasis by detecting a microRNA (miRNA) biomarker in a sample was developed.  Through the ability to stratify NSCLC patients with a high risk for brain metastasis,...
Published: 3/22/2019   |   Inventor(s): Glen Weiss, Seungchan Kim, Sara Nasser
Keywords(s):  
Category(s): Diagnostics
Methods For Detecting Burkholderia pseudomallei and Burkholderia mallei RNA with RT-qPCR
Researchers at TGen and Northern Arizona University (NAU) have developed a method for detecting Burkholderia pseudomallei and Burkholderia mallei from the 16S ribosomal RNA in a sample using a Reverse Transcriptase quantitative PCR (RT-qPCR) assay.  This assay enables faster, more sensitive detection of B. pseudomallei and B. mallei in a variety of...
Published: 2/6/2019   |   Inventor(s): James Schupp, Rebecca Colman, Jordan Buchhagen, Paul Keim, David Engelthaler
Keywords(s):  
Category(s): Diagnostics
Methods of Detecting Antiviral Drug Resistant H1N1 Influenza Variants
Researchers at TGen and Northern Arizona University (NAU) have developed a real-time PCR assay for detecting H1N1 influenza strains (which may also be known as as "novel H1N1," "swine flu," and "Mexican flu," among others) in a sample and informing clinicians whether the detected strain is a variant resistant to antiviral drugs, such as oseltamivir...
Published: 2/6/2019   |   Inventor(s): Paul Keim, David Engelthaler, Elizabeth Driebe
Keywords(s):  
Category(s): Diagnostics
Methods for Detecting and Differentiating Burkholderia pseudomallei and Burkholderia mallei with a Single Probe DNA SNP Assay
Researchers at TGen and Northern Arizona University (NAU) have developed a method for detecting Burkholderia pseudomallei and Burkholderia mallei from a single DNA SNP in a sample using Taqman SNP dual-probe allelic discrimination real-time PCR assay.  This assay provides a single-step, single reaction for identifying and differentiating between B....
Published: 2/6/2019   |   Inventor(s): Jolene Bowers, David Engelthaler, Paul Keim
Keywords(s):  
Category(s): Diagnostics
Methods of Quantifying Antiviral Drug Resistant Mutations in Influenza A
Researchers at TGen and Northern Arizona University (NAU) have developed a real-time allele specific mixture analysis (ASMA) qPCR assay for quantitatively analyzing the amount of antiviral drug resistant Influenza A mutants in a mixed viral sample.  This highly sensitive method provides a cost effective tool for clinical or public health laboratories...
Published: 2/6/2019   |   Inventor(s): Paul Keim, Elizabeth Driebe, David Engelthaler, Cindy Liu
Keywords(s):  
Category(s): Diagnostics
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