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Assay for Detecting and Quantifying Coccidioides
Researchers at TGen and Northern Arizona University (NAU) have developed a real-time qPCR assay for detecting and quantifying Coccidioides immitis and Coccidioides posadasii. The highly sensitive and specific assay can be used by clinicians in rapidly diagnosing Coccidioidomycosis. This assay can be particularly useful outside of the endemic regions...
Published: 8/31/2023
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Inventor(s): Paul Keim, David Engelthaler, Elizabeth Driebe
Keywords(s):
Category(s): Diagnostics, Environment
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Assays for the detection of Enterovirus D68
Researchers at TGen have developed assays for the detection of Enterovirus D68 (EV-D68) in complex patient samples. Both PCR and amplicon sequencing assays rapidly diagnose patients with EV-D68 respiratory illness, and can be used to assess a patient’s risk of acute flaccid myelitis (AFM) and potentially diagnose AFM. The assays can additionally...
Published: 1/3/2024
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Inventor(s): David Engelthaler, Jolene Bowers
Keywords(s):
Category(s): Diagnostics
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BioThreatSeq: an amplicon sequencing assay for detection and characterization of microbial pathogens in complex environmental and clinical samples
Researchers at TGen and Northern Arizona University have developed a multi-agent multi-locus amplicon sequencing protocol encompassing 79 targets aimed at detecting the presence or absence of five major biothreat agents: Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, Yersinia pestis and Francisella tularensis, as well as the presence...
Published: 1/27/2023
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Inventor(s): James Schupp, Jason Sahl, Paul Keim, David Engelthaler, David Wagner, Viacheslav Fofanov
Keywords(s):
Category(s): Diagnostics
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Methods of Detecting Antiviral Drug Resistant H1N1 Influenza Variants
Researchers at TGen and Northern Arizona University (NAU) have developed a real-time PCR assay for detecting H1N1 influenza strains (which may also be known as as "novel H1N1," "swine flu," and "Mexican flu," among others) in a sample and informing clinicians whether the detected strain is a variant resistant to antiviral...
Published: 2/14/2024
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Inventor(s): Paul Keim, David Engelthaler, Elizabeth Driebe
Keywords(s):
Category(s): Diagnostics
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Methods for Detecting and Differentiating Burkholderia pseudomallei and Burkholderia mallei with a Single Probe DNA SNP Assay
Researchers at TGen and Northern Arizona University (NAU) have developed a method for detecting Burkholderia pseudomallei and Burkholderia mallei from a single DNA SNP in a sample using Taqman SNP dual-probe allelic discrimination real-time PCR assay. This assay provides a single-step, single reaction for identifying and differentiating between B....
Published: 1/11/2024
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Inventor(s): Jolene Bowers, David Engelthaler, Paul Keim
Keywords(s):
Category(s): Diagnostics
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Methods of Quantifying Antiviral Drug Resistant Mutations in Influenza A
Researchers at TGen and Northern Arizona University (NAU) have developed a real-time allele specific mixture analysis (ASMA) qPCR assay for quantitatively analyzing the amount of antiviral drug resistant Influenza A mutants in a mixed viral sample. This highly sensitive method provides a cost effective tool for clinical or public health laboratories...
Published: 2/14/2024
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Inventor(s): Paul Keim, Elizabeth Driebe, David Engelthaler, Cindy Liu
Keywords(s):
Category(s): Diagnostics
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Allelic Discrimination Assays for MRSA Strains
Researchers at TGen and Northern Arizona University (NAU) have developed methods to rapidly identify and differentiate Methicillin-Resistant Staphylococcus aureus (MRSA) strains using real-time PCR assays. These allelic discrimination assays target SNPs to distinguish the clinically important MRSA strains USA100, USA300, USA 600, and other MRSA strains,...
Published: 1/11/2024
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Inventor(s): Paul Keim, Elizabeth Driebe, David Engelthaler, Jolene Bowers
Keywords(s):
Category(s): Diagnostics
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Assays for Antibiotic Resistance Gene Detection in Staphylococcus Strains
Researchers at TGen and Northern Arizona University (NAU) have developed a multiplex real-time PCR profiling assay for detecting antibiotic resistance-conferring genes in Staphylococcus strains. The multiplex assay determines the susceptibility of strains such as MRSA, MSSA, MRSE, and MSSE to antibiotics including aminoglycoside, vancomycin, penicillin,...
Published: 1/11/2024
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Inventor(s): Paul Keim, Elizabeth Driebe, David Engelthaler, Jolene Bowers
Keywords(s):
Category(s): Diagnostics
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MAMA Real-Time PCR Assay Panel for Genotyping Cyrptococcus gattii
Researchers at TGen and Northern Arizona University (NAU) have developed methods for genotyping Cryptococcus gattii using a mismatch amplification mutation assay (MAMA) real-time PCR assay panel. This assay panel provides a rapid method for genotyping of C. gattii molecular types VGI-VGIV and the dominate North American VGII molecular subtypes VGIIa-c...
Published: 2/14/2024
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Inventor(s): David Engelthaler, Elizabeth Driebe, Erin Kelley, Paul Keim
Keywords(s): Pathogens
Category(s): Genomics/Genetics, Diagnostics
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Repurposed Drugs for the Treatment of Fungal Infections Caused by Coccidioides
Researchers at TGen and Northern Arizona University (NAU) have developed an effective treatment for fungal infections caused by Coccidioides including the Valley Fever-causing species: Coccidioides immitis and Coccidioides posadasii in humans and companion animals (particularly canines). Repurposed drugs originally developed to inhibit hormone uptake...
Published: 1/3/2024
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Inventor(s): David Engelthaler, Elizabeth Driebe, Hongwei "Holly" Yin, Michael Valentine, Donald Chow, Jolene Bowers, Paul Keim
Keywords(s): Animal Health, Pathogens, Veterinary Medicine
Category(s): Therapeutics
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