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RNA Biomarkers for Mild Traumatic Brain Injuries
With generous support from Riddell, TGen has developed a noninvasive diagnostic method for mild traumatic brain injury (mTBI) using advanced genomic analyses of circulating DNA and extracellular RNA (exRNA) existing in bodily fluids that can be easily sampled in the field such as blood, urine, and salvia, and bodily fluids that can be further sampled...
Published: 4/2/2024
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Inventor(s): Kendall Van-Keuren Jensen, Matt Huentelman, Ashish Yeri
Keywords(s):
Category(s): Diagnostics
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TREM2 agonists for the preventative and therapeutic treatment of neugodegenerative disorders
Researchers at TGen have identified new potential preventative and therapeutic treatments for clinical management of Alzheimer’s disease and other neurodegenerative disorders with an immune neuorinflammatory component such as frontotemporal dementia, chronic traumatic encephalophathy, Down syndrome, or other diseases with an amyloid and/or tau...
Published: 3/4/2024
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Inventor(s): Matt Huentelman, Isabelle Schrauwen, Wayne Jepsen
Keywords(s):
Category(s): Therapeutics
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Biomarker Proxies for Standard Blood Chemistry Tests
Researchers at TGen have identified several RNA signatures that can be utilized to predict standard blood tests based on hematology or chemistry, for example, the results from a complete blood count panel, a comprehensive metabolic panel, a chemistry panel, or an endocrine panel (such as levels of thyroxine, T3, and TSH). The expression of these RNA...
Published: 3/29/2024
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Inventor(s): Matt Huentelman, Tim McDaniel, Marcus Naymik
Keywords(s):
Category(s): Medical, Diagnostics
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Dried Blood Spot Sequencing to Identify RNA Biomarkers
Researchers at TGen have developed a simple and non-invasive approach to sequence RNA biomarkers from a single dried blood spot. Using this RNA biomarker technology enables a relatively small volume biofluid sample from a patient (e.g., a drop of blood) to provide significant clinical information, such as identification, severity, stage, outcome, etc.,...
Published: 5/6/2024
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Inventor(s): Matt Huentelman
Keywords(s):
Category(s): Diagnostics
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