Search Results - daniel von hoff

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Methods for identifying and treating pancreatic cancer with ROCK1 therapeutic target
Researchers at TGen have developed a method for identifying and treating pancreatic cancer. Through the identification of the ROCK1 gene as a therapeutic target, pancreatic cancer can be detected and tumor cell proliferation and migration can be inhibited using the inventive methods.Pancreatic cancer is a prevalent cause of tumor related deaths in...
Published: 7/23/2018   |   Inventor(s): Haiyong Han, Clifford Whatcott, Daniel Von Hoff, Michael Barrett
Keywords(s):  
Category(s): Therapeutics
Methods for identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations
Summary of the InventionResearchers at TGen have patented a method for identifying molecules that reduce viability of cancer cells with a specific pattern of a loss-of-function genetic alteration. These molecules are identified by creating a matched pair of isogenic cell lines that differ only by a siRNA "knock down" of a single DPC4 gene....
Published: 8/17/2017   |   Inventor(s): Haiyong Han, Daniel Von Hoff, Hong Wang, Gary Flynn
Keywords(s):  
Category(s): Therapeutics